Description

• General description: N, N-Dimethylformamide (DMF) is an organic compound commonly used as a reagent as well as a solvent in organic synthesis. It plays multiple roles in various reactions such as formylating agent, dehydrating agent, reducing agent as well as a catalyst.
• Application: DMF can be used as:      A formylating agent for organometallic compounds.A reactant to prepare Vilsmeier reagent by reacting with phosphorus oxychloride.A reagent for amination of aryl chlorides in the presence of potassium t-butoxide.      A reducing agent for metal salts to prepare metal colloids.A catalyst for the regioselective silylation of unprotected carbohydrates.DMF can also be used in the following:      DMF-Phosgene catalytic system is used to prepare alkyl halides from alcohols.       DMF-POCl3 is used to convert acyclic and cyclic enolizable ketones to β-chloro-α, β-unsaturated aldehydes.DMF-POCl3 is used to synthesize quinoline-3-carbaldehydes from acylanilides.       DMF-SOCl2 combination is used to dehydrate oximes to nitriles.       DMF-Ag2O converts α-bromopropionamides to oxazolidinones.DMF is frequently used as a solvent in many chemical reactions, which require a high solvency power.