Description

• General description: Lithium chloride (LiCl) is a lithium salt. It is used as a source of chloride nucleophile as well as a source of chloride ligand in chemical synthesis. LiCl is also used as a desiccant in drying air streams.
• Application: Lithium chloride can be used as:       A source of chloride anion for the conversion of alcohols to alkyl chloride under Mitsunobu conditions.       An additive in the palladium-catalyzed coupling and carbonylative coupling reactions of organostannanes and vinyl triflates.       A reagent for the cleavage of protecting groups under mild conditions. It readily converts acetals and ketals to the corresponding carbonyl compounds.A reagent in the dehydrohalogenation of α-halocarbonyl compounds to α,β-unsaturated carbonyls compound in the presence of DMF.LiCl is also used with other reagents:       LiCl:DIPEA (1:1 molar ratio) is used in Horner–Wadsworth–Emmons alkenation reaction.       LiCl:Hexamethylphosphoric triamide is used in decarboxylative alkylation and chloride displacement reactions.LiCl is used as an additive in solid-phase peptide synthesis because it increases resin swelling and improves the efficiencies of complex coupling steps.
• Features and Benefits: Easy to handle       Weak Lewis acid       Highly soluble in water
• Other Notes: Go to Redi-Dri™ Product Listing 746460
• Legal Information: Redi-Dri is a trademark of Sigma-Aldrich Co. LLC