Stoelting™ Ugo Basile PAM Meter

Description

• Designed and validated specifically for the mechanical stimulation and assessment of joint pain, ideal for detecting arthritis in rats and mice
• Operation Specialized force sensor is worn on the thumb of the tester
• Each PAM device comes standard with two force sensors, which have been specifically designed to apply force to rat and mouse joints and pedal switch
• Computer software is also included for data acquisition
• Excellent for quantifying: Joint Sensitivity Chronic Joint Inflammation Arthritic Pain Arthritis is associated with chronic, debilitating pain in the joints
• Current metrics of arthritic pain are indirect, by scoring the level of motor activity or the animal's weight distribution
• Current indirect tests, such as the weight distribution correlate well with the level of joint pain, but such a metric is a composite picture of complex pain responses, and provides little discrete information about local stimulation and locally-evoked responses
• The quantification of localized joint hypersensitivity is common in the clinic, but not in animal experiments
• In this sense, the new PAM device represents a step forward toward a multifactorial measurement of pain-related behavior in animal research
• The PAM device is the first instrument designed specifically to apply force to the joint and automatically detect the animal's response
• Instrument Configuration Pressure transducers: the PAM device comes with 2 different transducers
• Each has been tested and validated in the mouse and rat knee joints: small transducer is flat and round (ideal for mouse knee joint), large transducer is flat and round (ideal for rat knee joint).