HP1 alpha Monoclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA1218-Each-of-1 | In Stock | ₹ 49,325.34 |
PIMA1218 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,325.34
GST (18%): ₹ 8,878.561
Total Price: ₹ 58,203.901
Antigen
HP1 alpha
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide; pH 7.2-7.4
Gene Accession No.
P45973
Gene Symbols
Cbx5
Immunogen
Purified recombinant fragment of human CBX5 (AA: 1-191) expressed in E. Coli
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
Monoclonal
Conjugate
Unconjugated
Gene
Cbx5
Gene Alias
2610029O15Rik, antigen p25, C75991, Cbx5, Cbx5 antibody, chromobox 5, chromobox homolog 5, chromobox homolog 5 (HP1 alpha homolog, Drosophila), chromobox protein homolog 5, chromobox-like protein 5, epididymis luminal protein 25, HEL25, heterochromatin protein 1 alpha, heterochromatin protein 1 homolog alpha, heterochromatin protein 1-alpha, HGNC:1555, HP1, HP1 alpha, HP-1 alpha antibody, HP1 alpha homolog, Hp1a, Hp1alpha, HP1-ALPHA, HP1Hs alpha, HP1Hs-alpha, mHP1(alpha)
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
23468
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA1-218 detects CBX5 from human and non-human primate samples
- CBX5 has an approximate molecular weight of 22.2kDa
- MA1-218 has been successfully used in Western blot, immunofluorescence,and immunohistochemistry applications
- The MA1-218 Immunogen is the purified recombinant fragment of human CBX5 (AA: 1-191) expressed in E
- Coli
- Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing
- It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure
- High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain
- Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3
- In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.