FBXW7 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5120961-Each-of-1 | In Stock | ₹ 43,079.46 |
PIPA5120961 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,079.46
GST (18%): ₹ 7,754.303
Total Price: ₹ 50,833.763
Antigen
FBXW7
Classification
Polyclonal
Conjugate
Unconjugated
Gene
FBXW7
Gene Alias
1110001A17Rik; AGO; archipelago; Archipelago homolog; CDC4; DKFZp686F23254; F-box and WD repeat domain containing 7; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein FBX30; F-box protein Fbxw6; F-box protein SEL-10; F-box/WD repeat-containing protein 7; F-box-WD40 repeat protein 6; FBW6; FBW7; Fbwd6; FBX30; Fbxo30; FBXW6; FBXW7; FLJ11071; FLJ16457; hAgo; hCdc4; homolog of C elegans sel-10; SEL10; SEL-10
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100360914, 50754, 55294
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q8VBV4, Q969H0
Gene Symbols
FBXW7
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 231-371 of human , (NP_3610141)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive test controls include: Jurkat, SH-SY5Y, MCF7, mouse testis, rat heart
- The target is usually found in the following locations: Cytoplasm, Nucleus, nucleolus, nucleoplasm
- Immunogen sequence: PTGLQEWLKM FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR IDTNWRRGEL K F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box
- The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination
- The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs
- FBXW7 was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats
- This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation
- Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers
- Multiple transcript variants encoding different isoforms have been found for this gene.