DIO1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143925-Each-of-1 | In Stock | ₹ 34,052.88 |
PIPA5143925 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,052.88
GST (18%): ₹ 6,129.518
Total Price: ₹ 40,182.398
Antigen
DIO1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Dio1
Gene Alias
5DI; D1; deiodinase, iodothyronine type I; deiodinase, iodothyronine, type I; Dio1; DIOI; hDido1; iodothyronine deiodinase type 1; ITDI1; thyroxine 5'-deiodinase; thyroxine deiodinase; thyroxine deiodinase type I (selenoprotein); thyroxine deiodinase, type I; TXDI1; Type 1 DI; type I iodothyronine deiodinase; Type-I 5'-deiodinase
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13370, 1733, 25430
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Concentration
500 μg/mL
Formulation
PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.
P24389, P49895, Q61153
Gene Symbols
Dio1
Immunogen
E.coli-derived human DIO1 recombinant protein (Position: K137-S249).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Lyophilized
Related Products
Description
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
- The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase
- It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3)
- It also degrades both hormones by inner ring deiodination (IRD)
- Alternative splicing results in multiple transcript variants encoding different isoforms
- Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination
- The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal
- Additional transcript variants have been described but are not supported by experimental evidence.