PEP0319
Invitrogen™ Human IRE1 alpha Synthetic Peptide
Manufacturer: Invitrogen™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PEP0319-Each-of-1 | In Stock | ₹ 16,247.84 |
PEP0319 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,247.84
GST (18%): ₹ 2,924.611
Total Price: ₹ 19,172.451
Gene ID (Entrez)
2081
Purification Method
purified
Common Name
Human IRE1 alpha
Content And Storage
-20°C
Format
Liquid
For Use With (Application)
Blocking Assay, Control
Lyophilized
No
Product Type
Peptide
Regulatory Status
RUO - research use only
Species
Human
Accession Number
O75460
Concentration
200 μg/mL
Description
Synthetic Peptide
Formulation
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
Gene Symbol
ERN1
Preservative
0.02% sodium azide
Quantity
50 μg
Storage Buffer
PBS
Related Products
Description
- IRE1p Synthetic Peptide, PEP-0319, from Invitrogen
- IRE1 alpha is the endoplasmic reticulum to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product
- IRE1 alpha protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals
- Specifically, IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator
- Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER
- Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER
- This peptide corresponds to 16 amino acids near the carboxy terminus of human IRE1p.PEP-0319 can be used as a blocking peptide with polyclonal antibody PA5-20189.