Interleukin-4 human

Description

• General description: Interleukin-4 (IL-4) is a pleiotropic cytokine[1] and a complex glycoprotein[2] mapped to human chromosome 5q31.1.[1] It is produced by mast cells, basophils and a subset of activated T cells.[2]
• Biochem/physiol Actions: Interleukin-4 (IL-4) interacts with interleukin 13 and is an interleukin-4 receptor ligand.[1] It regulates IgE and IgG1 production by B cells.[3] IL-4 favors glial and neuronal differentiation[4] and regulates differentiation of naive cluster of differentiation CD4+ T cells to the T helper type 2 (TH2) cells.[5] Polymorphism in the IL-4 gene is implicated in immune and inflammatory disorders.[1] In cerebral infarction, IL-4 levels are elevated.[1]
• Physical form: Lyophilized from a 0.2 μm filtered solution of 1x PBS.
• Preparation Note: HumanKine Interleukin-4 (IL-4), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 14-19 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
• Analysis Note: The activity is determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
• Legal Information: HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc