Description

• General description: Human serum albumin (HSA) is an unglycosylated, soluble, and globular monomeric protein.[1] It is abundantly found in the plasma,[2] with a multidomain comprising three homologous domains, called I, II, and III.[2][3] Three of these domains have subdomains A and B with common structural motifs. The HSA gene is localized on the human chromosome 4q13.3.[3]
• Application: Albumin, human serum, fraction V, high purity has been used to determine the binding affinity of nanobody α human serum albumin (HSA) to HSA and injected to detect the signals of tandem binding of human interleukin (IL-21R), IL-21-αHSA, and HSA.[4] It has also been used to study the effects of fetuin-A phosphorylation on calciprotein particles (CPP) uptake.[5]
• Biochem/physiol Actions: Human serum albumin (HSA) plays a major role as a carrier protein for fatty acids, thyroid hormones, and steroids.[1] It is involved in stabilizing extracellular fluid volume.[1] HSA is used to treat hemodialysis, acute liver failure, chronic liver disease.[2] It serves as an excipient for vaccines and therapeutic protein drugs.[1] HSA is implicated in biological applications, including ligand trapping, nano delivery of drugs, and fusion proteins.[2][1]
• Warning: Toxicity: Standard Handling (A)
• Preparation Note: Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
• Reconstitution: Alternatively, this product may be stored in the refrigerator (4°C) prior to reconstitution. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
• Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
• Disclaimer: RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.