Description

• General description: Adenine is a purine nucleobase.[1] It is part of DNA,[1] and RNA.[2] Adenine is also a component of cofactors (NAD, FAD) and signaling molecules (cAMP).
• Application: Adenine is suitable for use:as a component of boron-deficient media to grow yeast in order to assess whether yeast growth is stimulated by boron[3]as a food supplement for adult rats to investigate the effects of dietary adenine overload[4]as a nucleic acid base supplement in the basal media used to grow anaerobic Bacillus mojavensis and Bacillus subtilis in a study to show that DNA or deoxyribonucleosides are required for the anaerobic growth of these bacteria[5]as an additive to investigate the effects of adenine on CH4 production and on fermentation by ruminal batch cultures from nonlactating Holstein cows[6]as a part of adenine diet in rats in a study to identify blood markers for early stages of adenine-induced chronic kidney disease (CKD)[7]
• Biochem/physiol Actions: Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP.[1] ATP is the energy currency of the cell and is required during cellular metabolism.[8] Adenine is metabolized to is 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats.[9] Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds.