Description

• General description: Serum albumin is the most extensive plasma protein in the circulatory system.[1] It is produced within the liver and exported as a non-glycosylated protein to the blood plasma. The molecular weight of native serum albumin is around 66 kDa. Native serum albumin is a negatively charged protein.[2]Acetylation of bovine serum albumin particularly modifies lysine (Lys) residues with elevated frequency, with lesser degrees of modification of serine (Ser) and threonine (Thr) residues. MALDI-TOF mass spectrometry analysis of acetylated BSA has indicated an increased MW of about 3000, compared to native BSA (Ostatná, V. et al., J. Electroanalytical Chem., 821, 97-103 (2018)).. This acetylation process also derivatizes similar amino acid residues in any trace contaminating nucleases in the BSA, to inactivate that nuclease activity. This makes acetylated BSA useful in molecular biology applications where trace nuclease activity must be minimized.
• Application: Select the right albumin for your application with the Albumin Selection Guide.
• Biochem/physiol Actions: Native serum albumin plays a major role in maintaining the pH and osmotic pressure of the blood. It is also involved in transporting a diverse range of endogenous and exogenous metabolites, such as amino acids, fatty acids, drugs, steroids and metal ions.[1] Native serum albumin can have a role in modulating the levels of Ca2+ and Mg2+ metals in blood.[2]
• Features and Benefits: This acetylated BSA product has been tested for the following properties:DNase-free / Exonuclease-freeNickase-free / Endonuclease-freeProtease-freeRNase-free