Colistin sodium methanesulfonate
~11,500 U/mg
Manufacturer: Sigma Aldrich
CAS Number: 8068-28-8
Synonym(S): Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10000000 UNITS | C1511-10000000-UNITS | In Stock | ₹ 20,729.88 |
| 100000000 UNITS | C1511-100000000-UNITS | In Stock | ₹ 1,28,947.40 |
C1511 - 10000000 UNITS
In Stock
Quantity
1
Base Price: ₹ 20,729.88
GST (18%): ₹ 3,731.378
Total Price: ₹ 24,461.258
form
powder
Quality Level
200
specific activity
~11,500 U/mg
solubility
H2O: 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O
InChI
1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1
InChI key
WSDSONZFNWDYGZ-BKFDUBCBSA-I
Other Options
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Description
- General description: Chemical structure: peptide
- Application: Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.
- Biochem/physiol Actions: Colistin is a cationic, multicomponent lipopeptide antibiotic. It consists of a cyclic heptapeptide with tripeptide side chain, acylated at the N terminus by a fatty acid. It exhibits a potent anti-endotoxin.[1][2] Colistin interacts with the anionic LPS molecules and displaces calcium and magnesium ions. It solubilzes the cytoplasmic membrane resulting in leakage of cytosol which contributes to the bactericidal effect.[3][1]
- Other Notes: Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves