E2758

β-Estradiol

BioReagent, powder, suitable for cell culture

Manufacturer: Sigma Aldrich

CAS Number: 50-28-2

Synonym(S): 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

Select a Size

Pack Size SKU Availability Price
250 MG E2758-250-MG In Stock ₹ 4,124.33
1 G E2758-1-G In Stock ₹ 8,930.63
5 G E2758-5-G In Stock ₹ 36,393.65

E2758 - 250 MG

₹ 4,124.33

In Stock

Quantity

1

Base Price: ₹ 4,124.33

GST (18%): ₹ 742.379

Total Price: ₹ 4,866.709

biological source

synthetic (organic)

Quality Level

200

product line

BioReagent

Assay

≥98% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitablesingle cell analysis: suitable

mp

176-180 °C (lit.)

solubility

ethanol: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

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Description

  • General description: β-Estradiol or estradiol-17 β (E2) is secreted majorly by the large preovulatory follicles in the ovary. In addition, estradiol can be synthesized de novo from cholesterol have androgens synthesized from cholesterol. The aromatization of androgen by enzyme aromatase (P450arom) results in the β-estradiol production.[1]
  • Application: β-Estradiol has been used:as a component of Dulbecco′s modified Eagle medium (DMEM) for culturing mammary tumor cells[2]as a oestrogenic compound for testing neuroprotective effects[3]as a component of medium199 for culturing oocytes[4]
  • Biochem/physiol Actions: β-Estradiol (E2) is a major premenopausal hormone in women and is essential for spermiogenesis, sperm maturation and motility in men.[5] Cultured bone marrow stem cells (BMSCs) have ability to synthesize E2 and could be exploited for treating estrogen deficiency.[1] It mediates physiological functions through estrogen receptor (ER) α and ERβ.[6]
  • Physical form: powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
  • Reconstitution: To prepare a 20 μg/ml stock solution, add 1 ml absolute ethanol to 1 mg β-estradiol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

SAFETY INFORMATION

Pictograms

GHS08,GHS09

Signal Word

Danger

Hazard Statements

H351,H360FD,H362,H410

Precautionary Statements

P202 - P260 - P263 - P264 - P273 - P308 + P313

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves