S6201
Salinomycin, Ready Made Solution
from Streptomyces albus, ≥98% (HPLC)
Manufacturer: Sigma Aldrich
Synonym(S): Antibiotic 61477, Coxxistac
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 500 μL | S6201-500-μL | In Stock | ₹ 7,081.80 |
S6201 - 500 μL
In Stock
Quantity
1
Base Price: ₹ 7,081.80
GST (18%): ₹ 1,274.724
Total Price: ₹ 8,356.524
biological source
Streptomyces albus
Quality Level
200
Assay
≥98% (HPLC)
concentration
2 mg/ml
solubility
DMSO: solubleH2O: insolublealcohols: solublecarbon tetrachloride: solublechloroform: solubleethers and esters: solublehexane: soluble
antibiotic activity spectrum
neoplastics
Mode of action
cell membrane | interferes
shipped in
dry ice
storage temp.
−20°C
SMILES string
C[C@@H]1O[C@]([C@]2(C)CC[C@]3([C@H](O)C=C[C@]4(O[C@@]([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@@]5([H])[C@@H](C)CC[C@@]([C@H](C(O)=O)CC)([H])O5)=O)([H])[C@@H](C)C[C@H]4C)O3)O2)([H])CC[C@]1(O)CC
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Description
- General description: Chemical structure: polyether
- Application: Salinomycin, Ready Made Solution has been used as an inhibitor of endocytosis in primary pancreatic tumor cells.[1] It has also been used in sequential treatment of cancer cells to study resistance.[2]
- Biochem/physiol Actions: Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule.[3] Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K+ over other monovalent and divalent cations.[3] Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K+ channels, which enhances cell proliferation.[4][5] Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs.[5] Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.[5]
- Physical form: The product is supplied as a 2 mg/mL (2.66 mM) solution in DMSO, 0.2 μm-filtered.
SAFETY INFORMATION
WGK
WGK 2
Flash Point(F)
188.6 °F
Flash Point(C)
87 °C