S8406
Stromal Cell-Derived Factor 1β/pre-B Cell Growth Stimulating Factor human
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Manufacturer: Sigma Aldrich
Synonym(S): SDF-1β/PBSF
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 μG | S8406-10-μG | In Stock | ₹ 28,005.30 |
S8406 - 10 μG
In Stock
Quantity
1
Base Price: ₹ 28,005.30
GST (18%): ₹ 5,040.954
Total Price: ₹ 33,046.254
biological source
human
Quality Level
100
recombinant
expressed in E. coli
Assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
10-30 ng/mL ED50
mol wt
~8 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
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Description
- General description: C-X-C motif chemokine ligand 12 (CXCL12), also known as stromal cell-derived factor 1 α (SDF-1a), is encoded by the gene mapped to human chromosome 10q11.[1] Stromal cell-derived factor 1 α and β (SDF-1 α and β) are stromal derived CXC chemokines and signal through the C-X-C motif chemokine receptor-4 (CXCR4).[2] CXCL12 is mainly expressed in the inflamed and failing myocardium.[3]
- Application: Stromal Cell-Derived Factor 1β has been used to activate chemokine receptor-4 (CXCR4) and to further assess its role in tumor cell migration using chemotaxis assay.[4]
- Biochem/physiol Actions: C-X-C motif chemokine ligand 12 (CXCL12) is involved in inflammation, proliferation, tumorigenicity and metastasis.[5] CXCL12 exerts HIV (human immunodeficiency virus) suppressive activity in cells expressing the CXCR4 (C-X-C motif chemokine receptor 4).[6] It is overexpressed in breast carcinoma, ovarian carcinoma and papillary thyroid carcinoma. It enhances angiogenesis in the ischemic tissue. SDF1 is also implicated in neuroprotection after ischemic stroke with the help of CXCR4.[7][8]
- Physical form: Lyophilized from 30% acetonitrile and 0.1% trifluoracetic acid containing 0.5 mg of bovine serum albumin.
- Analysis Note: The biological activity is measured by its ability to chemoattract 8-10 day human T lymphocytes cultured in the presence of IL-2.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable