Description

• General description: The gene EPO (erythropoietin) is mapped to human chromosome 7q22.[1] It is a glycoprotein hormone. EPO is generated in fetal liver and adult kidney. However, it can also be secreted by other organs, such as the heart, brain and lungs.[2] EPO is a member of the EPO/TPO (thrombopoietin) family and is found in the plasma.[3]
• Application: EPO (erythropoietin) has been used as a component of the culture medium for cardiac stem cells.[4] In cultured cerebellar granule cells and hippocampal neurons, it has been used to study effect of EPO on glutamate release.[5] It has also been used as a component of endothelial differentiation medium.[6]
• Biochem/physiol Actions: EPO (erythropoietin) regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis.[3] It interacts with EPO receptor and is responsible for the cellular responses. EPO is expressed in many cancers, including breast cancer, renal cancer, gastric cancer, hepatocellular carcinoma and central nervous system tumors. In addition, it is a hypoxia responsive cytokine and a pro-angiogenic factor.[2] This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.[7] It can protect from brain damages due to ischemia and enhances memory as well as cognitive ability in humans suffering from vascular dementia.[7]
• Physical form: Lyophilized from a PBS solution.
• Preparation Note: Centrifuge the vial prior to opening.
• Reconstitution: Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.