T7883

Trimethoprim

≥98.5%

Manufacturer: Sigma Aldrich

CAS Number: 738-70-5

Synonym(S): 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, NSC 106568

Select a Size

Pack Size SKU Availability Price
5 G T7883-5-G In Stock ₹ 17,526.90
25 G T7883-25-G In Stock ₹ 37,839.90
100 G T7883-100-G In Stock ₹ 1,15,306.80

T7883 - 5 G

₹ 17,526.90

In Stock

Quantity

1

Base Price: ₹ 17,526.90

GST (18%): ₹ 3,154.842

Total Price: ₹ 20,681.742

Quality Level

200

Assay

≥98.5%

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

color

white to light yellow

antibiotic activity spectrum

Gram-negative bacteriaGram-positive bacteriamycobacteria

Mode of action

DNA synthesis | interferesenzyme | inhibits

storage temp.

2-8°C

SMILES string

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

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Description

  • General description: Chemical structure: pyrimidine
  • Application: Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections[1].
  • Biochem/physiol Actions: The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis[1].
  • Packaging: 5G,25G,100G
  • Other Notes: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

SAFETY INFORMATION

Pictograms

GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H361d

Precautionary Statements

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves