54802
1-Hydroxybenzotriazole hydrate
≥97.0% dry basis (T), for peptide synthesis
Manufacturer: Sigma Aldrich
CAS Number: 123333-53-9
Synonym(S): HOBt Hydrate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 250 G | 54802-250-G | In Stock | ₹ 38,104.00 |
54802 - 250 G
In Stock
Quantity
1
Base Price: ₹ 38,104.00
GST (18%): ₹ 6,858.72
Total Price: ₹ 44,962.72
product name
1-Hydroxybenzotriazole hydrate, ≥97.0% dry basis (T)
Quality Level
200
Assay
≥97.0% dry basis (T)
form
solid
composition
water, ~12%
reaction suitability
reaction type: Addition Reactions
mp
155-158 °C (lit.)
solubility
DMF: 0.1 g/mL, clear
application(s)
peptide synthesis
SMILES string
[H]O[H].On1nnc2ccccc12
Other Options
Related Products
Description
- General description: 1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids.[1] It is also used as a racemization suppressor during peptide synthesis.[2]
- Application: 1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare: Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.[2] Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.[3]
- Other Notes: Widely used additive to decrease racemization in the carbodiimide peptide coupling;[4] Racemization-free condensation of peptide fragments[5][6]
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501
Hazard Classifications
Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
WGK
WGK 1
Flash Point(F)
314.6 °F
Flash Point(C)
157 °C