8.52084

Fmoc-Dab(ivDde)-OH

Novabiochem®

Manufacturer: Sigma Aldrich

CAS Number: 607366-21-2

Synonym(S): Fmoc-Dab(ivDde)-OH, N-α-Fmoc-N-γ-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-diaminobutanoic acid

Select a Size

Pack Size SKU Availability Price
1 G 8.52084-1-G In Stock ₹ 18,590.00
5 G 8.52084-5-G In Stock ₹ 69,933.58

8.52084 - 1 G

₹ 18,590.00

In Stock

Quantity

1

Base Price: ₹ 18,590.00

GST (18%): ₹ 3,346.20

Total Price: ₹ 21,936.20

Quality Level

200

product line

Novabiochem®

Assay

≥95.0% (HPLC)≥98% (TLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

15-25°C

InChI

1S/C32H38N2O6/c1-19(2)15-26(29-27(35)16-32(3,4)17-28(29)36)33-14-13-25(30(37)38)34-31(39)40-18-24-22-11-7-5-9-20(22)21-10-6-8-12-23(21)24/h5-12,19,24-25,35H,13-18H2,1-4H3,(H,34,39)(H,37,38)/t25-/m0/s1

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Description

  • General description: This orthogonally-protected diaminobutyric acid derivative is based on the hindered Dde variant ivDde. The side-chain ivDde group is considerably more stable to piperidine than Dde and is less prone to migrate from protected to unprotected side-chains [1] and from side-chain to γ-amino group [2].When removing ivDde in the presence of allyl-based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group [3]. Associated Protocols and Technical ArticlesCleavage and Deprotection Protocols for Fmoc SPPSLiterature references[1] S. R. Chhabra, et al. (1998) Tetrahedron Lett., 39, 1603. [2] R. Wilhelm, personal communication. [3] B. Rohwedder, et al. (1998) Tetrahedron Lett., 39, 1175. [4] S. K. Sharma, et al. (1999) J. Peptide Res., 53, 501.
  • Linkage: Replaces: 04-12-1196
  • Analysis Note: Colour (visual): white to slight yellow to beigeAppearance of substance (visual): powderIdentity (IR): passes testEnantiomeric purity: ≥ 99.5 % (a/a)Purity (TLC(157A)): ≥ 98 %Purity (TLC(157B)): ≥ 98 %Assay (HPLC, area%): ≥ 95.0 % (a/a)Solubility (1 mmole in 2 ml DMF): clearly solubleWater (K. F.): ≤ 1.00 %To see the solvent systems used for TLC of Novabiochem® products please click here.
  • Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFETY INFORMATION

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable