Description

• General description: This support comprises the modified Rink amide linker attached via norleucine to MBHA resin, and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities.Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis Resins
• Application: Liquid chromatography-tandem mass spectrometry for forensic analysis: LSD-D₃ is utilized as an internal standard in the liquid chromatography-tandem mass spectrometry determination of LSD and its metabolites in forensic samples, enhancing accuracy and precision in the analytical results (Johansen and Jensen, 2005).Isotope dilution mass spectrometry in urine testing: Employed in the high-performance liquid chromatography-isotope dilution mass spectrometry (IDMS) method, LSD-D₃ serves as a crucial internal standard for the quantification of lysergide (LSD) in urine, aiding in precise and accurate drug testing (White et al., 1999).Automated extraction and LC/MS/MS confirmation: LSD-D₃ is used in the automated extraction of lysergic acid diethylamide from various biological matrices, followed by confirmation using LC/MS/MS. This application highlights its role in improving the efficiency and reliability of toxicological analyses (de Kanel et al., 1998).
• Linkage: Replaces: 01-64-0037
• Analysis Note: Colour (visual): white to light yellow to beigeAppearance of substance (visual): beadsLoading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.90 mmol/gTNBS-Test: passes testSwelling Volume (in DMF): lot specific resultSwelling Volume (in CH₂Cl₂): lot specific resultTotal swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 5.2 ml/gTotal swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/gThe polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh.
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany