Description

• General description: Spermidine is a polyamine[1] and a trivalent organic cation.[2]Spermidine is a naturally occurring polyamine compound with diverse biochemical properties. It plays a vital role in gene expression, participating in DNA replication, transcription, and translation processes. Spermidine is crucial for cell growth, proliferation, and differentiation, influencing cell cycle progression and tissue development. It possesses antioxidant activity, safeguarding cells against oxidative stress by scavenging free radicals. Spermidine also stimulates autophagy, promoting the turnover of damaged organelles and protein aggregates for cellular homeostasis. With neuroprotective effects, it supports neuronal survival, synaptic plasticity, and guards against neurodegenerative diseases. Additionally, spermidine modulates cellular signaling pathways involved in inflammation and immune responses.
• Application: Spermidine has been used:as a component of chromosome isolation buffer[3][4]as a component of transcription buffer[5]as a component of homogenization buffer[6]
• Biochem/physiol Actions: Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
• Features and Benefits: Versatile and adaptable for a wide variety of laboratory and research applicationsSuitable for Molecular Biology and Biochemical researchFree from DNase, RNase, NICKase, and protease Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applicationsTested for trace levels of Anions and Cations
• Caution: Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.
• Analysis Note: liquid or solid
• Other Notes: For additional information on our range of Biochemicals, please complete this form.