Antifoam C Emulsion

Description

• General description: Antifoam C emulsion is an aqueous emulsion containing 30% active silicone. This silicone-based antifoam emulsion[1] consists of non-ionic emulsifiers different from those in antifoam emulsions B and Y-30. Antifoam C emulsion can be prediluted with 3-10 parts of cool water to aid in dispersion. Prediluted suspensions should be used immediately. Antifoam C emulsion is typically effective at 1-10 ppm. The flow properties of antifoam C emulsion are such that it can be pumped on an as-needed basis to a fermenter system with sufficient agitation to disperse the antifoam. Antifoam C emulsion can be used to regulate headspace foaming in mammalian cell culture bioreactors up to 30 ppm concentration.[1]
• Application: Antifoam C emulsion has been used: as a supplement in RO-H2O and a chemically defined culture medium to determine volumetric mass transfer coefficient (kLa) of mammalian cell culture[2]as a component of feed medium[2],as a steam-sterilized antifoaming agent in a biocontroller for pH-stat fed-batch cultivations[3]as a supplement in fed batch medium to mimic the typical large-scale cultivation conditions[4]
• Features and Benefits: Minimizes compatibility issues with biological systemsHighly effective defoamer at low concentrationsHighly effective and versatile silicone defoamer
• Other Notes: A 30% aqueous emulsion of polydimethylsiloxane concentrate.