B9938

Calycosin

≥98% (HPLC)

Manufacturer: Sigma Aldrich

CAS Number: 20575-57-9

Synonym(S): 3′,7-Dihydroxy-4′-methoxy-isoflavone, 3′-Hydroxyformononetin, Cyclosin

Select a Size

Pack Size SKU Availability Price
10 MG B9938-10-MG In Stock ₹ 29,075.95

B9938 - 10 MG

₹ 29,075.95

In Stock

Quantity

1

Base Price: ₹ 29,075.95

GST (18%): ₹ 5,233.671

Total Price: ₹ 34,309.621

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to light yellow

solubility

methanol: 1 mg/mL, clear, colorless

application(s)

metabolomicsvitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

O=C1C(C(C=C2)=CC(O)=C2OC)=COC3=CC(O)=CC=C13

InChI

1S/C16H12O5/c1-20-14-5-2-9(6-13(14)19)15-8-12(18)11-4-3-10(17)7-16(11)21-15/h2-8,17,19H,1H3

InChI key

QAGGICSUEVNSGH-UHFFFAOYSA-N

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Description

  • General description: Calycosin is a plant estrogen exhibiting both agonistic and antagonistic attitude towards estrogen. It is an isoflavone, occurring as the primary component of the Radix astragali extract.[1][2]
  • Application: Calycosin has been used:to study its effect on the repression of glioblastomas by having an inhibitory effect on the expression of tyrosine-protein kinase Met (c-Met)[1]to analyze its effect on the growth of nasopharyngeal carcinoma cells by modulating the long non-coding RNA, Ewing sarcoma-associated transcript 1(EWSAT1)[2]to evaluate its effect on the left ventricular ejection fraction in rat model with myocardial ischemia[3]
  • Biochem/physiol Actions: Calycosin exhibits various therapeutic properties such as anti-inflammatory, antioxidant, antiviral, and neuroprotective effects.[1][4] It is shown to exercise its anticarcinogenic effects against the cluster of breast cancer, osteosarcoma, hepatocellular carcinoma, and colorectal cancer.[2] It is also being promoted as a probable treatment for myocardial infarction due to its ability to hasten the process of angiogenesis and increase the expression of vascular endothelial growth factor (VEGF).[3][5] It has been found to show hyperpermeability induced by the conditions of low osmolarity.[4] Finally, calycosin is being suggested to be used as a prodrug for the treatment of hypoxia-related vascular diseases.[6]

SAFETY INFORMATION

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H317

Precautionary Statements

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable