Description

• General description: Zinc granules are pure metallic zinc in a granular form, they provide a high surface area for increased reactivity.[1] They serve as a reducing agent, catalyst, or precursor for various chemical reactions. Zinc granules are commonly used for synthesis of organometallic compounds. It reacts with organic halides to form alkyl or aryl zinc compounds, which serve as powerful nucleophiles in carbon-carbon bond formations. This reaction, known as the Barbier reaction, enables the introduction of diverse functional groups into organic molecules.[2]Zinc granules also find application in the synthesis of pharmaceuticals and fine chemicals. They can be employed in the reduction of functional groups like nitro, nitrile, or azide to their corresponding amines. Additionally, zinc granules are involved in other carbon-carbon bond forming reactions, such as the Reformatsky reaction and the Simmons-Smith reaction.[2]
• Application: Zinc granules can be used to prepare: organozinc reagents commonly used in Negishi or Fukuyama couplings[3][4]Reformatsky reagents[5][6]Simmons-Smith reagents[7][8]