901487

(S,S,S)-AHPC hydrochloride

≥97%

Manufacturer: Sigma Aldrich

CAS Number: 2115897-23-7

Synonym(S): (2S,4S)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, E3 Ligase ligand negative control epimer, Ligand for PROTAC® research, VH032 negative control

Select a Size

Pack Size SKU Availability Price
10 MG 901487-10-MG In Stock ₹ 20,037.08
100 MG 901487-100-MG In Stock ₹ 56,590.00

901487 - 10 MG

₹ 20,037.08

In Stock

Quantity

1

Base Price: ₹ 20,037.08

GST (18%): ₹ 3,606.674

Total Price: ₹ 23,643.754

ligand

VH032

Quality Level

100

Assay

≥97%

form

powder or crystals

reaction suitability

reagent type: ligand

storage temp.

2-8°C

SMILES string

N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@H](O)C1)=O)C(C)(C)C.Cl

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Description

  • Application: (S,S,S)-AHPC (HCl salt) is a ligand used as a negative control for (S,R,S)-AHPC (cat# 901490) in the recruitment of the von Hippel–Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.
  • Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationSelective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4Small-Molecule PROTACS: New Approaches to Protein DegradationIdentification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)
  • Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable