917478
BocA1V1PF2
≥95%
Manufacturer: Sigma Aldrich
Synonym(S): (S)-2-((S)-1-((S)-2-((S)-2-((tert-Butoxycarbonyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoic acid, AVP ligand, IAP E3 ligase lead for protein degrader research, SNIPER building block
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | 917478-100-MG | In Stock | ₹ 49,546.03 |
917478 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 49,546.03
GST (18%): ₹ 8,918.285
Total Price: ₹ 58,464.315
ligand
BocA1V1PF2
Quality Level
100
Assay
≥95%
form
powder
reaction suitability
reagent type: ligand
functional group
carboxylic acid
storage temp.
2-8°C
SMILES string
C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O
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Description
- Application: BocA1V1PF2 is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. A C-terminal variant of BocA1V1PF2 is also available as A1V1PF2-OEt (917710).BocA1V1PF2 conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC® degrader libraries: Degrader Building Blocks916927 BocA1V1PF2-OC6-NH2 hydrochloride917184 BocA1V1PF2-OC10-NH2 hydrochloride917435 BocA1V1PF2-OPEG1-NH2 hydrochloride917680 BocA1V1PF2-OPEG3-NH2 hydrochlorideTechnology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands
- Other Notes: In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)SNIPERs−Hijacking IAP activity to induce protein degradationE3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable