929441
C5-Pomalidomide-piperazine hydrochloride
≥95%
Manufacturer: Sigma Aldrich
CAS Number: 2228029-82-9
Synonym(S): 2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 929441-50-MG | In Stock | ₹ 17,760.00 |
929441 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 17,760.00
GST (18%): ₹ 3,196.80
Total Price: ₹ 20,956.80
ligand
pomalidomide
Quality Level
100
Assay
≥95%
form
powder
storage temp.
2-8°C
SMILES string
O=C1N(C2CCC(NC2=O)=O)C(C3=CC=C(N4CCNCC4)C=C31)=O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | eMolecules Ambeed / 2-(26-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-13-dione hydrochloride / 100mg / 787726543 / A1581459 / / 2228029-82-9 / [null] / 378.810 / C17H19ClN4O4 | -- | ₹ 36,019.90 | |
| | Thalidomide-piperazine (hydrochloride) | -- | ₹ 11,550.60 - ₹ 1,46,649.84 | |
| | Thalidomide-piperazine hydrochloride | -- | ₹ 59,293.08 - ₹ 3,16,400.88 |
Related Products
Description
- Application: Protein degrader building block C5-Pomalidomide-piperazine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a nitroveratryloxycarbonyl group that can undergo photolysis to form a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Protein Degrader Building Block
- Other Notes: Targeted Protein Degradation by Small Molecules. Small-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1B
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable