Description

• General description: Trimethyltin chloride is an organotin reagent widely used in transferring trimethylstannyl groups onto the substrates to synthesize various organostannanes. Trimethylstannyl compounds derived from this reagent, are extensively used in the palladium-catalyzed Stille coupling reactions.
• Application: Trimethyltin chloride can be used as a precursor to synthesize trimethyltin hydride, cyanide, methoxide, azide, and lithium compounds.[1]It can also be used as a reagent to prepare: Organotrimethyltin derivatives by reacting with organocopper compounds via transmetalation reaction.[1] Acetophenone by palladium-catalyzed coupling reaction with benzoyl chloride.[1]Optically active propargyl trimethylstannane by treating with chiral allenyltitanium.[1] Trimethylstannyl nucleophiles, which are applicable in the formation of Sn-C bonds via SN2 reactions, SRN1 reactions, and halogen-metal exchanges.[1]Carbocycles by reacting with unactivated dienes or trienes via radical-mediated carbocyclization reaction in the presence of NaBH3CN and a catalytic amount of AIBN.[1] Me3SnCl can also be used as a Lewis acid catalyst in asymmetric allylic alkylation reactions.[1]