Description

• General description: N-Maleoyl-β-alanine (3-maleimidopropanoic acid) is an aliphatic N-substituted maleimide.[1] It is one of the component of the stabilizing solution for EC145 (a folate-targeted vinca alkaloid conjugate) used in rodent pharmacokinetic studies.[2]
• Application: N-Maleoyl-β-alanine (3-maleimidopropanoic acid, N-(2-carboxyethyl)maleimide)) is the suitable reagent used in the following studies:To decrease the biotin binding affinity of Avd(S16C) (avidin with a single point mutation S16C).[3]As a side chain reactive agent to modify tryptic peptides that result in mass shifts indicating the presence of cysteine residues.[4]To preblock Xenopus laevis oocytes for exposed cysteines used as an expression system in the study of conformational changes in cASIC1a Receptors.[5]It may be used in the following studies:As a protective agent for keratin fiber in high temperature process.[1]As a non-cleavable maleimido moiety during the synthesis of tetrawalled molecular umbrella-octaarginine conjugates.[6]Synthesis of organotin carboxylates of N-Maleoyl-β-alanine.[7]To functionalize the gold surfaces to interact with cysteine-modified peptide.[8]Preparation of cross-linked dextran–poly(ethylene glycol) hydrogel substrate.[9]
• Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.