46-941-0
Tocris Bioscience™ Ro 5-3335
Manufacturer: Tocris Bioscience™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 46-941-0-Each-of-1 | In Stock | ₹ 30,972.72 |
46-941-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 30,972.72
GST (18%): ₹ 5,575.09
Total Price: ₹ 36,547.81
Purity
>98%
Quantity
10 mg
Molecular Weight (g/mol)
259.69
Gene Alias
CBFβ-Runx1 inhibitor II
Product Type
Ro 5-3335
Inhibitors
Ro 5-3335
Related Products
Description
- Ro 5-3335 is a core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM)
- Represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ
- Reduces leukemia burden in a mouse model
- Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos
- Also a Tat antagonist; inhibits HIV-1 replication in vitro .