465110
Tocris Bioscience™ JW 67
Manufacturer: Fischer Scientific
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Purity
>97%
Product Type
JW 67
Inhibitors
JW 67
Quantity
10 mg
Molecular Weight (g/mol)
394.38
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Description
- Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation
- Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways
- Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 μM).