51-341-0
Tocris Bioscience™ MRT 67307 dihydrochloride
Manufacturer: Tocris Bioscience™
CAS Number: 1781882-89-0
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 51-341-0-Each-of-1 | In Stock | ₹ 26,994.18 |
51-341-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 26,994.18
GST (18%): ₹ 4,858.952
Total Price: ₹ 31,853.132
Purity
>98%
Quantity
10 mg
Molecular Weight (g/mol)
537.52
CAS
1781882-89-0
Product Type
MRT 67307 dihydrochloride
Inhibitors
MRT 67307 dihydrochloride
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | MRT67307 HCl | -- | ₹ 3,764.64 - ₹ 3,22,561.20 |
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Description
- MRT 67307 dihydrochloride is a salt inducible kinase (SIK) inhibitor (IC50 values are 67, 250 and 430 nM for SIK2, SIK1 and SIK3 respectively)
- Also inhibits TBK1, MARK1-4, IKKε and NUAK1 (IC50 values are 19, 27-52, 160 and 230 nM respectively)
- Has no effect on IKKα or IKKβ
- Induces IL-10 secretion and inhibits TNF-α and IL-6 secretion in bacterial LPS-stimulated macrophages
- Also enhances IL-1-induced activation of NFκB-dependent gene transcription in mouse embryonic fibroblast (MEF) cells
- Inhibits autophagy.