5545700
Tocris Bioscience™ AZ 20
Potent and selective ATR kinase inhibitor; antitumor
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
AZ 20
Molecular Weight (g/mol)
412.51
Inhibitors
AZ 20
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Description
- Potent and selective ATR kinase inhibitor (IC50 = 5 nM)
- Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK
- Inhibits cell growth in cell lines with high baseline levels of replication stress
- Displays antitumor effects in vivo .