5545753

Tocris Bioscience™ CMPD-1

Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor

Manufacturer: Fischer Scientific

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Purity

>99%

Product Type

CMPD-1

Molecular Weight (g/mol)

349.4

Inhibitors

CMPD-1

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Description

  • Non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM)
  • Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2
  • Also tubulin polymerization inhibitor
  • Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.