5545775
Tocris Bioscience™ E 64
Potent and irreversible cysteine protease inhibitor
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
E 64
Molecular Weight (g/mol)
357.41
Inhibitors
E 64
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Description
- Potent and irreversible cysteine protease inhibitor (IC50 values are 1.4, 2.5 and 4.1 nM for cathepsin K, L and S respectively
- Also inhibits papain, calpain, cathepsin B and cathepsin H
- Has no effect on serine proteases
- Reduces HSC-3 tongue cancer cell invasion and induces oxidative stress and apoptosis in filarial parasites
- Also inhibits autophagy-associated lysosomal degradation in vitro .