5545831
Tocris Bioscience™ Indibulin
Microtubule destabilizer
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Purity
>98%
Product Type
Indibulin
Molecular Weight (g/mol)
389.83
Inhibitors
Indibulin
Related Products
Description
- Microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3 μM)
- Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036 - 0.285 μM)
- Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo
- Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules
- Displays oral availability and efficacy towards MDR tumor cells.