5545890
Tocris Bioscience™ ML 347
Potent and selective ALK1 and ALK2 inhibitor
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
ML 347
Inhibitors
ML 347
Gene Alias
LDN 193719, 1 lWY, VU0469381
Molecular Weight (g/mol)
352.39
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Description
- Potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2
- Exhibits no activity at ALK4, ALK5 or in a panel of related kinases
- Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).