5545931
Tocris Bioscience™ NSC 23766
Selective inhibitor of Rac1-GEF interaction; antioncogenic
Manufacturer: Fischer Scientific
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Product Type
NSC 23766
Molecular Weight (g/mol)
530.97
Inhibitors
Rho GTPase Inhibitors
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Description
- Selective inhibitor of Rac1-GEF interaction
- Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ∽ 50 μM) without affecting Cdc42 or RhoA activation
- Inhibits Rac1-mediated cell functions and is reported to reverse tumor cell phenotypes in prostate cancer cells.