5545962
Tocris Bioscience™ PHT 427
Dual Akt and PDK1 inhibitor; antitumor
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
PHT 427
Molecular Weight (g/mol)
409.61
Inhibitors
PHT 427
Related Products
Description
- Dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively)
- Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro
- Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.