5546110
Tocris Bioscience™ XAP 044
Potent and selective mGlu7 antagonist
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
XAP 044
Molecular Weight (g/mol)
380.13
Inhibitors
XAP 044
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Description
- Potent and selective mGlu7 antagonist (IC50 = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice
- Displays no effects on the LTP of mGlu7 deficient mice
- Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD)
- Exhibits anti-anxiety effects in rodent models
- Brain penetrant.