BDB556465
BD Ac-DEVD-CHO Inhibitor
Manufacturer: BD
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For Use With (Application)
Functional assay
Content And Storage
-20°C
Molecular Weight (g/mol)
502.5
Form
Purified
Storage Buffer
Lyophilized powder
Quantity
1 mg
Inhibitors
Ac-DEVD-CHO
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Description
- Members of ICE/CED-3 cysteine protease family have key roles in inflammation and mammalian apoptosis
- The ICE family member Caspase-3 (also known as CPP32, Yama, apopain) is activated early in apoptosis and appears to be involved in proteolysis of several important molecules, including poly (ADP ribose) polymerase (PARP) Synthetic tetrapeptide inhibitor for Caspase-3 Used in protease assays Cleaves PARP from 116kD to 85kD residual fragment Cleavage site in PARP is C-terminal to Asp-216 Upstream sequence of cleavage site, DEVD (Asp-Glu-Val-Asp), is utilized as basis for highly specific Caspase-3 substrate, Ac-DEVD-AMC and Caspase-3 inhibitor,Ac-DEVD-CHO Storage Buffer: Lyophilized powder Format: Purified Functional assay