BDB556472
BD Caspase-3
Manufacturer: BD
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Concentration
0.2mg/mL
Formulation
50mM Tris (pH 8) with 100mM NaCl and 50mM Imidazole
Quantity
5μg
Cross Reactivity
Human
Form
Purified
For Use With (Application)
Enzyme Assay
Name
Human Caspase-3 Active Form Recombinant Protein
Storage Requirements
-80°C
Recombinant
Recombinant
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Description
- Caspases are cysteine proteases that play central role in apoptosis
- The caspase family was discovered by searching human cDNA libraries for sequences homologous to ced-3, a C
- Each caspase is synthesized as an inactive proenzyme that is processed by cleavage at asparte residues by another protease or by self-proteolysis
- Fas and tumor necrosis factor receptor type 1 (TNFR1) One of their substrates is poly (ADP ribose) polymerase (PARP) Cleave PARP from its 116kDa form to 85kDa residual fragment The cleavage site in PARP is C-terminal to Asp-216 Utilized as basis for highly specific caspase-3 substrates such as Ac(N-acetyl)-DEVD-AFC (7-amino-4-trifluoromethylcourmarin) and Ac(N-acetyl)-DEVD-AMC (7-amino-4-methylcoumarin) as well as caspase-3 aldehyde inhibitor Ac-DEVD-CHO Storage Buffer: 50mM Tris (pH 8.0) with 100mM NaCl and 50mM imidazole Format: Purified