5546168
Tocris Bioscience™ ML 297
Selective Kir3.1/3.2 (GIRK1/2) channel activator
Manufacturer: Fischer Scientific
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Purity
>99%
Product Type
ML 297
Molecular Weight (g/mol)
328.32
Inhibitors
ML 297
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Description
- Selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively)
- Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters
- Prevents PTZ -induced epileptic seizures in mice
- Brain penetrant.