Pro-Lab Diagnostics™ Prolex™ E. coli Non-O157 Latex Test Reagent Kit

Description

• Although E
• coli O157 is the most common cause of STEC illness, it has now been recognized that non-O157 strains of E
• coli cause severe human disease that is comparable with that caused by E
• coli O157
• Of these strains, E
• coli O26 is the most commonly isolated and can cause hemolytic uremic syndrome (HUS), as several other serotypes can
• The following strains are the next most commonly isolated: E
• coli O103, E
• coli O111, E
• coli O145, E
• coli O45 and E
• coli O121
• These serotypes have also been shown to cause significant human disease
• In the United States, the CDC has recommended that all clinical laboratories screen for STEC
• Polystyrene beads are sensitized with immunoglobulins against each of the serotype-specific E
• coli somatic antigens (E
• coli O26, E
• coli O103, E
• coli O111, E
• coli O145, E
• coli O121 or E
• coli O45) When coated polystyrene particles are mixed with fresh organisms of the corresponding E
• coli serotype, bacteria will bind to the antibody, causing particles to visibly agglutinate (positive reaction) Bacteria not of serotypes O26, O103, O111, O145, O121 or O45 will not bind to antibody and will not result in agglutination (negative reaction)