Invitrogen™ Dynabeads™ RNA Binding Buffer

Description

• Dynabeads RNA Purification Buffer is intended for use with Dynabeads Carboxylic Acid for RNA Purification, providing a simple, scalable, and automation-ready solution for purification of crude RNA produced by in vitro transcription (IVT)
• The combination is particularly suitable where flexibility and high purity are required, such as in discovery phase of vaccine development and following the solid-phase IVT reaction with Dynabeads Streptavidin for In Vitro Transcription
• This buffer combined with Dynabeads Carboxylic Acid for RNA Purification offer efficiency, scalability (micrograms to grams of mRNA) in manual and automated workflows, and quality to navigate from RNA-based drug discovery to commercial manufacturing without incurring extra time or costs from switching technology or raw material
• Crude RNA from an IVT reaction is mixed with the beads and the buffer is added
• The RNA binds to the bead surface and the remaining components of the reaction mixture are removed by applying a magnet and discarding the supernatant
• Scripts are available for automated purification workflows with KingFisher systems
• The buffer is offered here as a stand-alone product
• It is also included in the kits below: Dynabeads RNA Purification Kit (Cat
• No
• 65030D) Dynabeads In Vitro Transcription and RNA Purification Kit (Cat
• No
• 65034D) To learn more about other products and support documentation available for GMP-compliant manufacturing of mRNA vaccines and therapeutics visit: thermofisher.com/dynabeadsmrna