Thermo Scientific™ TMT11-131C Label Reagent

Description

• Tandem mass tag (TMT) reagents are specially designed to enable identification and quantitation of proteins in different samples using tandem mass spectrometry
• The TMT11-131C tag structure is identical to the other TMT10pex tags, but the TMT11-131C mass reporter is labeled with only 13C isotopes
• The addition of the TMT11-131C tag enables separation of the 131-mass reporter ion of the original TMT10plex reagents into N and C variants, creating an 11th channel for relative quantitation using high resolution Orbitrap MS instruments
• The advantages of TMT label reagents include increased multiplexed relative quantitation, increased sample throughput, and fewer missing quantitative values among samples
• TMT10plex label reagents plus TMT11-131C is ideal for analysis of multiple protein samples from inhibitor dose response experiments, time course experiments, or to improve statistics on biological replicates
• Features of this TMT11-131C Label Reagent include: • Multiplex —concurrent MS analysis of up to 11 samples derived from cells, tissues, or biological fluids • Robust —increased multiplex capability results in fewer missing quantitative values among samples and higher confidence among replicates • Efficient —amine-reactive, NHS-ester-activated reagents ensure efficient labeling of all peptides regardless of protein sequence or proteolytic enzyme specificity • Compatible —optimized for use with high resolution Thermo Scientific Orbirtrap MS/MS platforms, with data analysis fully supported by Proteome Discoverer 2.3 TMT11-131C is available as a standalone tag (Cat
• No
• A34807, A37724), as part of this TMT10plex Isobaric Label Reagent Set plus TMT11-131C, or as part of the complete 11plex set of reagents in a 96-well plate format
• When combined with the industry-leading, high resolution Orbitrap instruments and software, TMT reagents provide integrated total solutions for quantitative protein expression analysis.