11-016-5CBC25
MilliporeSigma™ Calbiochem™O-GlcNAcase Inhibitor, TMG
Manufacturer: MilliporeSigma™
CAS Number: 1009816-48-1
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 11-016-5CBC25-Each-of-1 | In Stock | ₹ 20,049.27 |
11-016-5CBC25 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,049.27
GST (18%): ₹ 3,608.869
Total Price: ₹ 23,658.139
Color
Off-white
CAS
1009816-48-1
Formula Weight
248.3g/mol
Content And Storage
Toxicity: Harmful, Store at -20°C, Protect from light, Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Quantity
25 mg
Description
≥98% by HPLC
Molecular Formula
C9H16N2O4S
Solubility
DMSO or H2O
Form
Solid
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences Thiamet G >=98% (HPLC) | 1009816-48-1 | MFCD15144964 | 25MG | -- | ₹ 53,286.77 | |
| | Sigma Aldrich Fine Chemicals Biosciences Thiamet G | 1009816-48-1 | MFCD15144964 | 5 mg | -- | ₹ 13,730.67 | |
| | Selleck Chemical LLC Thiamet G 25mg 1009816-48-1 | -- | ₹ 37,988.64 | |
| | 5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)- | -- | ₹ 2,053.44 - ₹ 75,207.24 | |
| | 1009816-48-1 | Thiamet g | -- | ₹ 3,080.16 - ₹ 1,33,986.96 |
Related Products
Description
- A cell-permeable, blood-brain barrier-permeant, orally active aminothiazoline that effectively increases O -GlcNAc level of cellular proteins both in cultures (EC 50 = 30 nM, EC max = 200nM in PC3) in vitro and in rats (50mg/kg i.v.; 200mg/kg via drinking water ad libitum ) and mice (500mg/kg via drinking water ad libitum ) in vivo by inhibiting O-GlcNAcase/OGA-mediated O -GlcNAc cleavage in a substrate-competitive ( K i = 21nM), time- and dose-dependent, and highly selective manner
- TMG long-term treatment in murine AD model effectively prevents loss of motor neurons and reduces NFTs in brain without apparent effect on Tau hyperphosphorylation
- O -GlcNAcylation is also reported to slow down heat-induced sTAB1 (TAK1-binding protein) aggregation and modulate CK2α kinase activity and substrate selectivity in vitro .