20-027-525MG

MilliporeSigma™ Calbiochem™ Berberine Chloride

Manufacturer: MilliporeSigma™

CAS Number: 633-65-8

Select a Size

Pack Size SKU Availability Price
Each of 1 20-027-525MG-Each-of-1 In Stock ₹ 3,892.98

20-027-525MG - Each of 1

₹ 3,892.98

In Stock

Quantity

1

Base Price: ₹ 3,892.98

GST (18%): ₹ 700.736

Total Price: ₹ 4,593.716

Color

Yellow

CAS

633-65-8

Formula Weight

371.81g/mol

Content And Storage

Protect from light

Quantity

25 mg

Description

95% by HPLC (NMR if no UV signal)

Molecular Formula

C20H18NO4+Cl-

Solubility

DMSO or H2O

Form

Powder

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Description

  • A highly potent and selective oxysterol EBI2 (GPR183) agonist (K d ) = 450 pM in a saturation binding assay, and EC 50 = 140 pM over EC 50 = 2.1nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay)
  • Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC 50 = 2nM), but not in control cells
  • Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4 + T-cells in a dose-dependent manner
  • In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.