40-009-150MG
MilliporeSigma™ Calbiochem™ HIF-Hydroxylase Inhibitor, DMOG
Manufacturer: MilliporeSigma™
CAS Number: 89464-63-1
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 40-009-150MG-Each-of-1 | In Stock | ₹ 9,432.13 |
40-009-150MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 9,432.13
GST (18%): ₹ 1,697.783
Total Price: ₹ 11,129.913
Color
White
CAS
89464-63-1
Formula Weight
175.1g/mol
Content And Storage
Hygroscopic
Quantity
50 mg
Description
98% by HPLC
Molecular Formula
C6H9NO5
Solubility
DMSO
Form
Solid
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-15893 100mg , DMOG CAS:89464-63-1 Purity:>98% | -- | ₹ 11,229.75 | |
| | Apexbio Technology LLC cell-permeable, competitive HIF-PH inhibitor 89464-63-1. MFCD05865098 | -- | ₹ 5,133.60 | |
| | Sigma Aldrich Fine Chemicals Biosciences DMOG >=98% (HPLC) | 89464-63-1 | MFCD05865098 | 50MG | -- | ₹ 42,506.21 | |
| | Sigma Aldrich Fine Chemicals Biosciences DMOG | 89464-63-1 | MFCD05865098 | 10mg | -- | ₹ 10,795.96 | |
| | Cayman Chemical DMOG, 89464-63-1, 100 mg | -- | ₹ 13,578.37 | |
| | Cayman Chemical DMOG, 89464-63-1, 500 mg | -- | ₹ 57,526.27 | |
| | DMOG | -- | ₹ 6,417.00 - ₹ 52,020.48 |
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Description
- A cell-permeable 2-OG (2-oxoglutarate) analog that is expected to act as a competitive inhibitor against all 2-OG-dependent dioxygenases
- Effectively upregulates normoxia HIF-α transcription activity (effective conc
- = 1mm in cultures) by inhibiting HIF-PH- (HIF-α-prolyl hydroxylase) catalyzed ODD (oxygen-dependent degradation domain) Prolyl hydroxylation (Pro 564 and Pro 530 in HIF-1α and HIF-2α, respectively) and aspartyl/asparanginyl β-hydroxylase-catalyzed CAD Asp hydroxylation (Asn 803 and Asn 851 in HIF-1α and HIF-2α, respectively), resulting in a blockage of pVHL (von Hippel-Lindau) ubiquitin ligase complex-mediated HIF-α degradation and a simultaneous promotion of HIF CAD (COOH-terminal activation domain) p300/CBP association
- DMOG is also demonstrated to augment artery ligation-induced up-regulation of HIF-1α and FLK (by 100% and 40%, respectively, in 11 days; 8mg/0.5 ml/animal/i.p.; q.o.d.) in muscle tissues in a murine ischaemic model in vivo .