40-100-31GM

MilliporeSigma™ Calbiochem™ (±)-Ibuprofen

Manufacturer: MilliporeSigma™

CAS Number: 15687-27-1

Select a Size

Pack Size SKU Availability Price
Each of 1 40-100-31GM-Each-of-1 In Stock ₹ 6,684.80

40-100-31GM - Each of 1

₹ 6,684.80

In Stock

Quantity

1

Base Price: ₹ 6,684.80

GST (18%): ₹ 1,203.264

Total Price: ₹ 7,888.064

Color

White

Target Proteins

COX-1

Molecular Formula

C13H18O2

Solubility

DMSO or EtOH

Form

Solid

Description

98% by titration

CAS

15687-27-1

Formula Weight

206.3g/mol

Content And Storage

Protect from light

Quantity

1 g

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Description

  • A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC 50 = 4.85μM)
  • Inhibits COX-2 at higher concentrations (IC 50 = 223μM)
  • Blocks aspirin inactivation of COX-1 (EC 50 antagonism of 200μM aspirin = 290 nM)
  • Shown to reduce the total Aβ secretion (Amyloid β 40 and 42 ) in human neuronal cells and offers neuroprotection against glutamate-, nitric oxide-, and superoxide-induced damage
  • Reported to activate peroxisome proliferator-activated receptors (PPAR) α and γ in both CV-1 and C3H10T1/2 cells (∽100μM-500μM).